Description
We are seeking a highly motivated Research Fellow with a strong background in human stem cell biology developmental biology neuroscience cancer biology bioengineering or a related field. Candidates with hands-on experience in human induced pluripotent stem cell (hiPSC) culture directed differentiation 3D organoid models or microfluidic cell and tissue culture systems are particularly encouraged to apply.
The fellow will contribute to the development of advanced human-relevant experimental platforms including brain organoids brain tumor organoids patient-derived tumor organoids Alzheimers disease (AD) hiPSC-derived neural models and brain organoids vascularized brain organoids blood-brain barrier (BBB) models and assembloids and microfluidic organ-on-chip and brain-organoid-on-chip systems. Research may include generation of patient-specific hiPSC models from primary patient cells differentiation into neural and neurovascular cell types development of multicellular 3D tissue models and integration of neural vascular immune and tumor components within microfluidic chip-based platforms to model the brain microenvironment neurovascular interface brain tumors and neurodegenerative disease. A major goal is to use these advanced human model systems for brain tumor biology Alzheimers disease and neurodegenerative disease modeling therapeutic discovery drug delivery BBB penetration studies high-content and functional drug screening and cell-based therapeutic development. The fellow may develop patient-specific AD hiPSC-derived neurons glial cells neurovascular models and brain organoids to investigate disease mechanisms and evaluate candidate therapeutic strategies. The fellow will also have opportunities to explore stem cell-based and engineered cell therapies including evaluation of cell survival differentiation migration functional integration and therapeutic activity in advanced organoid and organ-on-chip models. The fellow will work collaboratively with investigators in chemical biology medicinal chemistry pharmacology cancer biology neuroscience neurodegenerative disease cell therapy regenerative medicine bioengineering genomics and computational biology to develop innovative therapeutic drug-screening and disease-modeling technologies.Preferred experience includes one or more of the following: hiPSC/hESC culture and differentiation; patient-derived hiPSC disease models; Alzheimers disease or other neurodegenerative disease iPSC models; brain tumor organoids or patient-derived tumor organoids; stem cell-derived brain organoids; organoid and assembloid engineering; microfluidics lab-on-a-chip organ-on-chip or tissue-on-chip technologies; BBB or neurovascular models; cell therapy or regenerative medicine; CRISPR/Cas9 genome editing; advanced microscopy and quantitative imaging; transcriptomic or single-cell analyses; and pharmacological high-throughput or high-content screening.
Prior expertise in chemical biology pharmacology or cell therapy is desirable but not required. We are particularly interested in candidates with strong expertise in stem cell biology brain organoids brain tumor organoids neurodegenerative disease modeling or microfluidic bioengineering who are enthusiastic about applying these technologies to translational therapeutic development through multidisciplinary collaborations. QualificationsMust have a Ph.D. M.D. or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship at Mayo Clinic or elsewhere.
Required Experience:
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